1,4-Dioxane hydrochloride → HCID 67516969, compound

HRID 2173299Notes

Reaction equation

HRID 2173299 reaction equation
[C:1]([C:3]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[C:7]=2[CH:6]=[CH:5][CH:4]=1)#[N:2].[ClH:26].O1CCOCC1>>[ClH:26].[N:13]1([CH2:12][CH:8]2[C:7]3[CH:6]=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[C:11]=3[O:10][CH2:9]2)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67517382HCID 67517382, compound

Product 1

HCID 67516969HCID 67516969, compound

Procedure

Compound tert-butyl 4-[(7-cyano-2,3-dihydro-1-benzofuran-3-yl)methyl]piperazine-1-carboxylate (76 mg, 0.22 mmol) was added HCl/dioxane (4 N) and the resulting mixture was stirred at room temperature for 3 hours, and then the solvents were removed under vacuum to give the crude 3-(piperazin-1-ylmethyl)-2,3-dihydro-1-benzofuran-7-carbonitrile hydrochloride.

Workup

  1. customthe solvents were removed under vacuum

Sources & evidence

ORD record
ord-31ba23cfbbcc4fd59c18968fe233b6fc
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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