Hydrogen chloride-ethyl acetate → HCID 67517704, compound

HRID 2173326Notes

Reaction equation

HRID 2173326 reaction equation
[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([CH2:12][C:13]([N:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[O:14])=[N:10][CH:11]=2)[CH:5]=[N:4][N:3]=[N:2]1.[ClH:28].CCOC(C)=O>>[ClH:28].[N:15]1([C:13](=[O:14])[CH2:12][C:9]2[CH:8]=[CH:7][C:6]([N:1]3[CH:5]=[N:4][N:3]=[N:2]3)=[CH:11][N:10]=2)[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67517556HCID 67517556, compound

Product 1

HCID 67517704HCID 67517704, compound

Procedure

A mixture of tert-butyl 4-{[5-(1H-tetrazol-1-yl)pyridin-2-yl]acetyl}piperazine-1-carboxylate (30 mg, 0.08 mmol) in HCl/EtOAc (5 mL) was stirred for 3 hours at room temperature. The reaction mixture was concentrated under reduce pressure to give 1-(piperazin-1-yl)-2-[5-(1H-tetrazol-1-yl)pyridin-2-yl]ethanone hydrochloride. MS m/z 274 (M+1)+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-7a1639d605e14dd88b3aa0b634c337c2
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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