反应详情

A mixture of ethyl [5-(hydroxyamino)pyrazin-2-yl]acetate (2.8 g, 14.2 mmol) and Pd(OH)2 (3 g, 10%) in 150 mL of methanol was stirred at room temperature under 50 psi of H2 for 2 hours before filtration. The filtrate was concentrated to afford ethyl (5-aminopyrazin-2-yl)acetate. 1H-NMR (400 MHz, CDCl3) δ ppm 7.96 (s, 1H), 7.94 (s, 1H), 4.59 (brs, 2H), 4.18 (q, J=7.2 Hz, 2H), 3.71 (s, 2H), 1.25 (t, J=7.2 Hz, 3H).

1. concentrationThe filtrate was concentrated