HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 6-bromo-1-benzofuran-3-carboxylate → HCID 67517858, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 6-bromo-1-benzofuran-3-carboxylate | HCID 19371000 | — |
| Reactant | Phthalimide potassium salt | HCID 24194345 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 67517858 | HCID 67517858 | — |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
A solution of ethyl 6-bromo-1-benzofuran-3-carboxylate (14.90 g, 55.4 mmol) in 200 mL of DMA was added potassium phthalimide (10.3 g, 55.4 mmol) and CuI (10.6 g, 55.4 mmol) and the mixture was stirred at 150° C. under nitrogen atmosphere overnight. The reaction mixture was concentrated under vacuum, and the residue was dissolved in DCM, filtered through Celite®. The filtration was concentrated and purified with silica gel column chromatograph to give ethyl 6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-benzofuran-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-4f33c8213622445386f2f2d185cd4427 |
| Source note | uspto-grants-2015_06 |