tert-Butyl piperazine-1-carboxylate → 5-[2-oxo-2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one

HRID 2173352Notes

Reaction equation

HRID 2173352 reaction equation
Cl.[N:2]1([C:8](=[O:21])[CH2:9][C:10]2[CH:15]=[CH:14][C:13](N3C=NN=N3)=[CH:12][CH:11]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.N1([C:28]([O:30][C:31](C)(C)C)=[O:29])CCNCC1.O=C1C2C=CC(CC(O)=O)=CC=2CO1>>[O:21]=[C:8]([N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1)[CH2:9][C:10]1[CH:11]=[CH:12][C:13]2[C:28](=[O:29])[O:30][CH2:31][C:14]=2[CH:15]=1

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 675172361-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochlorideHCID 67518033(1-Oxo-1,3-dihydro-2-benzofuran-5-yl)acetic acid

Product 1

HCID 675168485-[2-oxo-2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one

Procedure

5-[2-Oxo-2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one was prepared in an analogous fashion as described above in the synthesis of 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride starting from tert-butyl piperazine-1-carboxylate and (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetic acid.

Sources & evidence

ORD record
ord-e9f5c83afa5a4e5da4259d1156adbcc1
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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