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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2173352Generated: October 30, 2026

tert-Butyl piperazine-1-carboxylate → 5-[2-oxo-2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one

https://huagongshe.com/reaction/2173352

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Reactant1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochlorideHCID 67517236—
Reactant(1-Oxo-1,3-dihydro-2-benzofuran-5-yl)acetic acidHCID 67518033—
Product5-[2-oxo-2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-oneHCID 67516848—

Reaction Steps

5-[2-Oxo-2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one was prepared in an analogous fashion as described above in the synthesis of 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride starting from tert-butyl piperazine-1-carboxylate and (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09056859B2
Source datasetuspto-grants-2015_06
ORD IDord-e9f5c83afa5a4e5da4259d1156adbcc1
Source noteuspto-grants-2015_06