HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → 2,5-Difluoro-4-[2-oxo-2-(piperazin-1-yl)ethyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 4-Cyano-2,5-difluorophenylacetic acid | HCID 67513341 | — |
| Reactant | 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride | HCID 67517236 | — |
| Product | 2,5-Difluoro-4-[2-oxo-2-(piperazin-1-yl)ethyl]benzonitrile | HCID 67516933 | — |
Reaction Steps
2,5-difluoro-4-[2-oxo-2-(piperazin-1-yl)ethyl]benzonitrile was prepared in an analogous fashion as described above in the synthesis of 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride starting from tert-butyl piperazine-1-carboxylate and (4-cyano-2,5-difluorophenyl)acetic acid. LC/MS: [(M+1)]+=266.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-887c6542a6d74713afb62ffd82f9a280 |
| Source note | uspto-grants-2015_06 |