Acetic Acid → HCID 67515686, compound

HRID 2173363Notes

Reaction equation

HRID 2173363 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:5]=[C:4]([N+:15]([O-])=O)[N:3]=1.CC(O)=O>CO.[Pd]>[NH2:15][C:4]1[N:3]=[C:2]([CH3:1])[C:7]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 77230645HCID 77230645, compound

Product 1

HCID 67515686HCID 67515686, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of ethyl 2-(2-methyl-6-nitropyridin-3-yl)propanoate (1.6 g, 6.7 mmol), 10% Pd/C (0.1 g) and AcOH (3 mL) in MeOH (50 mL) was stirred over night under 1 atm of H2 at room temperature. The mixture was filtered and concentrated to give the crude product ethyl 2-(6-amino-2-methylpyridin-3-yl)propanoate.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-502f4218f66f4c7ba059ec69947359e5
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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