HCID 86693023, compound → HCID 67516507, compound

HRID 2173377Notes

Reaction equation

HRID 2173377 reaction equation
CC(C)(C)C([NH:5][C:6]1[N:11]=[CH:10][C:9]2[CH:12]([C:15]([O-:17])=[O:16])[CH2:13][CH2:14][C:8]=2[CH:7]=1)=O>Cl>[NH2:5][C:6]1[N:11]=[CH:10][C:9]2[CH:12]([C:15]([OH:17])=[O:16])[CH2:13][CH2:14][C:8]=2[CH:7]=1

Participants

3

Reactant 1

HCID 86693023HCID 86693023, compound

Product 1

HCID 67516507HCID 67516507, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3-[(2,2-dimethylpropanoyl)amino]-6,7-dihydro-5H-cyclopenta[c]pyridine-7-carboxylate (0.624 mg, 1.96 mmol) in 6N hydrochloric acid (25 mL) was heated to reflux for 24 h. The solution was cooled and concentrated to provide 3-amino-6,7-dihydro-5H-cyclopenta[c]pyridine-7-carboxylic acid which was used without further purification in the next step. LC/MS (M+1)+=179.0;

Workup

  1. temperatureto reflux for 24 h
  2. temperatureThe solution was cooled
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-17eba7f97a9c4a6fb9cee33013b3c4a3
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

Loading…