反应详情

温度

120 °C

A mixture of diethyl (2,5-difluoro-4-nitrophenyl)propanedioate (700 mg, 2.2 mmol) with HOAc (10 mL) and HCl (6 N, 10 mL) was heated under N2 at 120° C. for 2.5 hours and then allowed to cool and stirred overnight. Most of the solvent was removed by evaporation and then water was added. The mixture was extracted with EtOAc. The organic layer washed with brine, dried over anhydrous Na2SO4 and concentrated to give (2,5-difluoro-4-nitrophenyl)acetic acid.

1. temperatureto cool
2. customMost of the solvent was removed by evaporation
3. additionwater was added
4. extractionThe mixture was extracted with EtOAc
5. washThe organic layer washed with brine
6. dry with materialdried over anhydrous Na2SO4
7. concentrationconcentrated