Methanol → 6-methyl-5-[2-(4-{[4-(1h-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one

HRID 2173435Notes

Reaction equation

HRID 2173435 reaction equation
[CH3:1][C:2]1[C:3]([CH2:12][CH:13]=O)=[CH:4][C:5]2[CH2:9][O:8][C:7](=[O:10])[C:6]=2[CH:11]=1.Cl.[N:16]1([C:21]2[CH:26]=[CH:25][C:24]([CH2:27][C:28]([N:30]3[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]3)=[O:29])=[CH:23][CH:22]=2)[CH:20]=[N:19][N:18]=[N:17]1.C([BH3-])#N.[Na+].CO>C(O)(=O)C>[CH3:1][C:2]1[C:3]([CH2:12][CH2:13][N:33]2[CH2:32][CH2:31][N:30]([C:28](=[O:29])[CH2:27][C:24]3[CH:23]=[CH:22][C:21]([N:16]4[CH:20]=[N:19][N:18]=[N:17]4)=[CH:26][CH:25]=3)[CH2:35][CH2:34]2)=[CH:4][C:5]2[CH2:9][O:8][C:7](=[O:10])[C:6]=2[CH:11]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 5003444Sodium cyanoborohydrideHCID 675172361-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochlorideHCID 772306752-(6-methyl-1-oxo-3H-2-benzofuran-5-yl)acetaldehyde

Product 1

HCID 573312106-methyl-5-[2-(4-{[4-(1h-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a flask charged with (6-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde (100 mg, 0.53 mmol) was added 1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazine hydrochloride (162 mg, 0.53 mmol), sodium cyanoborohydride (165 mg, 2.6 mmol), methanol (10 mL), and a drop of acetic acid. The mixture was allowed to stir at RT for 16 hours. LC showed formation of the desired product. The solvent was removed under reduced pressure. The residue was redissolved in DMSO-water, and purified by mass-directed HPLC. LC/MS: (1E, m/z) (M+1)+=447.3;

Sources & evidence

ORD record
ord-c5f08645aa194c54a57e7eaa37f668bb
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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