Sodium Carbonate → HCID 67518225, compound

HRID 2173440Notes

Reaction equation

Br[C:2]1[CH:7]=[C:6]([N:8]2[CH:12]=[N:11][N:10]=[N:9]2)[CH:5]=[CH:4][C:3]=1[CH2:13][C:14]([N:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]2[CH:33]=[CH:32][C:27]3[C:28](=[O:31])[O:29][CH2:30][C:26]=3[CH:25]=2)[CH2:18][CH2:17]1)=[O:15].[C:34]1(B(O)O)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.C([O-])([O-])=O.[Na+].[Na+]>C1(C)C=CC=CC=1.C(O)C>[N:8]1([C:6]2[CH:5]=[CH:4][C:3]([CH2:13][C:14]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]4[CH:33]=[CH:32][C:27]5[C:28](=[O:31])[O:29][CH2:30][C:26]=5[CH:25]=4)[CH2:18][CH2:17]3)=[O:15])=[C:2]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH:7]=2)[CH:12]=[N:11][N:10]=[N:9]1

Participants

Conditions

Temperature: 80 °C

Procedure

A mixture of 5-[2-(4-{[2-bromo-4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one (40 mg, 0.08 mmol), PhB(OH)2(24 mg, 0.2 mmol), Na2CO3 (42 mg, 0.4 mmol) and Pd(PPh)4(10 mg) in 3 mL of toluene and 3 mL of ethanol was heated to 80° C. under N2 overnight. The solution was concentrated to get the crude product, which was purified via prep-TLC to afford 5-[2-(4-{[5-(1H-tetrazol-1-yl)biphenyl-2-yl]acetyl}piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one. 1H-NMR (300 MHz, CDCl3) δ ppm 9.0 (s, 1H), 7.84 (d, J=8.0 Hz, 1H), 7.67˜7.70 (m, 1H), 7.53˜7.63 (m, 2H), 7.44˜7.49 (m, 3H), 7.30˜7.37 (m, 4H), 5.28 (s, 2H), 3.58˜3.74 (m, 4H), 3.17˜3.30 (m, 2H), 2.87˜2.98 (m, 2H), 2.39˜2.69 (m, 4H), 2.22˜2.36 (m, 2H).

Workup

concentrationThe solution was concentrated
customto get the crude product, which
customwas purified via prep-TLC

Sources & evidence

ORD record: ord-c2ebf385cc1d4ce497a55f0cfdc10e41
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09056859B2

Reaction notes

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