HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2173445Generated: October 30, 2026
4-Nitrophenethyl bromide → 1-{8-[2-(4-nitrophenyl)ethyl]-3,8-diazabicyclo[3.2.1]oct-3-yl}-2-[4-(1H-tetrazol-1-yl)pheny]ethanone
https://huagongshe.com/reaction/2173445
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Nitrophenethyl bromide | HCID 79266 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone | HCID 67517231 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-{8-[2-(4-nitrophenyl)ethyl]-3,8-diazabicyclo[3.2.1]oct-3-yl}-2-[4-(1H-tetrazol-1-yl)pheny]ethanone | HCID 69087471 | — |
Reaction Steps
1-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone (100 mg, 0.335 mmol) was combined with 1-(2-bromoethyl)-4-nitrobenzene (77 mg, 0.34 mmol) and Hunig's base (43.3 mg, 0.335 mmol) in acetonitrile (1 mL) and stirred at 60° C. for 5 h. Purification by mass-directed HPLC afforded the title compound. LC/MS: [(M+1)]+=448.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09056859B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-fb462cf5fe504140b7fc7ab12c110a64 |
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| Source note | uspto-grants-2015_06 |
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