3-Nitrophenethyl bromide → 1{4-[2-(3-Nitrophenyl)ethyl]piperazin-1-yl}-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone
Reaction equation
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1.[N+](C1C=CC(CC[N:24]2[CH:29]3CC[CH:25]2[CH2:26][N:27]([C:32](=[O:45])[CH2:33][C:34]2[CH:39]=[CH:38][C:37]([N:40]4[CH:44]=[N:43][N:42]=[N:41]4)=[CH:36][CH:35]=2)[CH2:28]3)=CC=1)([O-])=O>>[N+:10]([C:6]1[CH:5]=[C:4]([CH2:3][CH2:2][N:24]2[CH2:25][CH2:26][N:27]([C:32](=[O:45])[CH2:33][C:34]3[CH:35]=[CH:36][C:37]([N:40]4[CH:44]=[N:43][N:42]=[N:41]4)=[CH:38][CH:39]=3)[CH2:28][CH2:29]2)[CH:9]=[CH:8][CH:7]=1)([O-:12])=[O:11]Participants
3
Procedure
1-{4-[2-(3-Nitrophenyl)ethyl]piperazin-1-yl}-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone was prepared from 1-(2-bromoethyl)-3-nitrobenzene and 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-ylphenyl]ethanone in an analogous fashion to that described for the synthesis of 1-{8-[2-(4-nitrophenyl)ethyl]-3,8-diazabicyclo[3.2.1]oct-3-yl}-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone. LC/MS: [(M+1)]+=422.
Sources & evidence
- ORD record
- ord-0d9eefd182354f9b91b4568067455fe0
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09056859B2
Reaction notes
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