反应详情

To a solution of N-Methoxy-N-methyl-2,1,3-benzoxadiazole-5-carboxamide (630 mg, 3.04 mmol) in THF (5 mL) cooled to −40° C. was added methyl lithium solution (1.6M, 2.28 mL, 3.65 mmol). The reaction mixture was stirred at the same temperature for 1 h, then was quenched by addition of 1M HCl. The mixture was extracted with ethyl acetate and the organic layer was dried over MgSO4. Purification my flash chromatography afforded the title compound. 1H-NMR (500 MHz, CDCl3) δ ppm 8.48 (s, 1H), 8.02 (d, 1H), 7.91 (d, 1H), 2.72 (s, 3H).

1. customwas quenched by addition of 1M HCl
2. extractionThe mixture was extracted with ethyl acetate
3. dry with materialthe organic layer was dried over MgSO4
4. customPurification my flash chromatography