HCID 67517237, compound → HCID 67517684, compound

HRID 2173454Notes

Reaction equation

HRID 2173454 reaction equation
[N:1]1([C:7](=[O:20])[CH2:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH:19]=[N:18][N:17]=[N:16]3)=[CH:11][CH:10]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:21]1[CH2:23][CH:22]1[C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[C:30](=[O:34])[O:29][CH2:28][CH2:27]2>C(O)C>[OH:21][CH:22]([C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[C:30](=[O:34])[O:29][CH2:28][CH2:27]2)[CH2:23][N:4]1[CH2:5][CH2:6][N:1]([C:7](=[O:20])[CH2:8][C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH:19]=[N:18][N:17]=[N:16]3)=[CH:13][CH:14]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 67517237HCID 67517237, compoundHCID 77230677HCID 77230677, compound

Product 1

HCID 67517684HCID 67517684, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone (200 mg, 0.734 mmol), 6-(oxiran-2-yl)-3,4-dihydro-1H-isochromen-1-one (140 mg, 0.734 mmol) in ethanol was heated in a microwave reactor at 130° C. for 1 h. The reaction mixture was concentrated and the residue was purified by preparative TLC to afford the title compound. LC/MS: [(M+1]+=463.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by preparative TLC

Sources & evidence

ORD record
ord-e0ccfd8755d244789003f7b93230291c
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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