Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 5-tert-Butyl-3-(4-methoxy-benzyl)-7-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 86683345 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 178441794 | HCID 178441794 | — |
Reaction Steps
The crude 5-tert-Butyl-3-(4-methoxy-benzyl)-7-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine was treated with triethylsilane in TFA and heated to 70° C. for 20 h and evaporated. The crude material was used without further purification in the consecutive step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09056866B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-b84377c8e4e14e75856c4e7099cdf20c |
|---|
| Source note | uspto-grants-2015_06 |
|---|
