Triethylsilane → HCID 178441794, compound

HRID 2173620Notes

Reaction equation

HRID 2173620 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:27][C:26]([F:29])([F:28])[C:25]([F:31])([F:30])[CH2:24]2)[C:8]2[N:13]=[N:12][N:11](CC3C=CC(OC)=CC=3)[C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[C:1]([C:5]1[N:6]=[C:7]([N:23]2[CH2:27][C:26]([F:28])([F:29])[C:25]([F:30])([F:31])[CH2:24]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 866833455-tert-Butyl-3-(4-methoxy-benzyl)-7-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Product 1

HCID 178441794HCID 178441794, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
70 °C

Procedure

The crude 5-tert-Butyl-3-(4-methoxy-benzyl)-7-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine was treated with triethylsilane in TFA and heated to 70° C. for 20 h and evaporated. The crude material was used without further purification in the consecutive step.

Workup

  1. customevaporated
  2. customThe crude material was used without further purification in the consecutive step

Sources & evidence

ORD record
ord-b84377c8e4e14e75856c4e7099cdf20c
Source dataset
uspto-grants-2015_06
Patent number
US09056866B2

Reaction notes

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