Tert-butyl 3-bromobutanoate → tert-Butyl 3-[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethylamino]-butanoate

HRID 2173763Notes

Reaction equation

HRID 2173763 reaction equation
Br[CH:2]([CH3:11])[CH2:3][C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[OH:12][CH2:13][C:14]1[CH:19]=[C:18]([O:20][CH2:21][CH2:22][NH:23]S(C2C=CC=CC=2[N+]([O-])=O)(=O)=O)[CH:17]=[C:16]([CH2:36][OH:37])[N:15]=1>>[OH:12][CH2:13][C:14]1[CH:19]=[C:18]([O:20][CH2:21][CH2:22][NH:23][CH:2]([CH3:11])[CH2:3][C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[CH:17]=[C:16]([CH2:36][OH:37])[N:15]=1

Participants

3

Reactant 2

HCID 57092335Tert-butyl 3-bromobutanoateHCID 66713939N-[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-2-nitro-benzenesulfonamide

Product 1

HCID 66716520tert-Butyl 3-[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethylamino]-butanoate

Procedure

Prepared as for Ex. 2, starting with tert-butyl 3-bromo-butyrate and N-[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-2-nitro-benzenesulfonamide:

Workup

  1. customPrepared as for Ex

Sources & evidence

ORD record
ord-09db2ba024d141b8af0405ea338b80cd
Source dataset
uspto-grants-2015_06
Patent number
US09056914B2

Reaction notes

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