反应详情

(4R)-4-Acetylthio-2-pyrrolidone (10 g) is dissolved in toluene (100 ml), and thereto is added gradually phosphorus pentasulfide (9.5 g), and the mixture is stirred at room temperature for 20 minutes. To the reaction solution are added water and ethyl acetate, and the mixture is stirred at room temperature for 1.5 hour. The insoluble materials are removed by filtration, and the organic layer is washed with water, dried, and evaporated to remove the solvent. The residue is recrystallized from toluene to give (+)-(4R)-4-acetylthiopyrrolidine-2-thione (7.9 g).

1. stirringthe mixture is stirred at room temperature for 1.5 hour
2. customThe insoluble materials are removed by filtration
3. washthe organic layer is washed with water
4. customdried
5. customevaporated
6. customto remove the solvent
7. customThe residue is recrystallized from toluene