反应详情

温度

100 °C

2-((5-Methyl-1-tosyl-7-vinyl-1H-indol-4-yl)methyl)-1H-benzo[d]imidazole-5-carbonitrile (23 mg, 0.049 mmol) was dissolved in EtOH (1 mL) and KOH (27.7 mg, 0.493 mmol) and isoamylamine (0.11 mL, 0.986 mmol) were added and the mixture was stirred at 100° C. in the microwave for 30 minutes. The mixture was then stirred at 100° C. in the microwave for another 15 minutes. The reaction was purified directly by flash chromatography (0-100% EtOAc in heptanes) to provide the title compound. MS (ESI+) m/z 313.1 (M+H).

1. stirringThe mixture was then stirred at 100° C. in the microwave for another 15 minutes
2. customThe reaction was purified directly by flash chromatography (0-100% EtOAc in heptanes)