Methyl bromoacetate → HCID 86701716, compound

HRID 2174082Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([C:17]3[C:25]([O:26][CH3:27])=[CH:24][C:23]([CH3:28])=[C:22]4[C:18]=3[CH:19]=[CH:20][N:21]4[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])([OH:16])[C:12]([F:15])([F:14])[F:13])=[N:8][C:7]=2[CH:36]=1)#[N:2].Br[CH2:38][C:39]([O:41][CH3:42])=[O:40]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([C:17]3[C:25]([O:26][CH3:27])=[CH:24][C:23]([CH3:28])=[C:22]4[C:18]=3[CH:19]=[CH:20][N:21]4[C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])([O:16][CH2:38][C:39]([O:41][CH3:42])=[O:40])[C:12]([F:14])([F:13])[F:15])=[N:8][C:7]=2[CH:36]=1)#[N:2]

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 86701717HCID 86701717, compound

Product 1

HCID 86701716HCID 86701716, compound

Procedure

The title compound was synthesized from tert-butyl 4-(1-(5-cyanobenzo[d]oxazol-2-yl)-2,2,2-trifluoro-1-hydroxyethyl)-5-methoxy-7-methyl-1H-indole-1-carboxylate (Example 128-A) and methyl 2-bromoacetate following Example 109-A. MS (ESI+) m/z 574.3 (M+H).

Sources & evidence

ORD record: ord-0484a0864a494c209a694d17d74907b6
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09056874B2

Reaction notes

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