N-Iodosuccinimide → HCID 68285982, compound

HRID 2174203Notes

Reaction equation

HRID 2174203 reaction equation
[F:1][C:2]1[C:11]([F:12])=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[I:13]N1C(=O)CCC1=O>C(O)(=O)C>[F:1][C:2]1[C:11]([F:12])=[C:10]2[C:5]([CH:6]=[C:7]([I:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 3025799Quinoline, 7,8-Difluoro-

Product 1

HCID 68285982HCID 68285982, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

185.5 g (1.12 mol) of 7,8-difluoroquinoline, 505.4 g (2.25 mol) of N-iodosuccinimide and 927 mL of acetic acid were placed in a 3 L eggplant flask containing a stirrer, followed by stirring the mixture for 30 hours at 90° C. After cooling the resultant, the precipitated crystals were filtered and dried.

Workup

  1. additioncontaining a stirrer
  2. temperatureAfter cooling the resultant
  3. filtrationthe precipitated crystals were filtered
  4. customdried

Sources & evidence

ORD record
ord-433be3a89c8542e3ab1a413ea7718263
Source dataset
uspto-grants-2015_06
Patent number
US09060517B2

Reaction notes

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