HCID 86661534, compound → HCID 58069948, compound

HRID 2174308Notes

Reaction equation

HRID 2174308 reaction equation
C([Si](C)(C)OC(CCCCCCCC(O)=O)CCCCCCCC(O)=O)(C)(C)C.[Si]([O:37][CH:38]([CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O:67][CH2:68]/[CH:69]=[CH:70]\[CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH3:76])=[O:66])[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][C:46]([O:48][CH2:49]/[CH:50]=[CH:51]\[CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH3:57])=[O:47])(C(C)(C)C)(C)C>C1(C)C=CC=CC=1.C(Cl)Cl>[OH:37][CH:38]([CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][C:46]([O:48][CH2:49]/[CH:50]=[CH:51]\[CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH3:57])=[O:47])[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O:67][CH2:68]/[CH:69]=[CH:70]\[CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH3:76])=[O:66]

Participants

5

Reactant 2

HCID 86661534HCID 86661534, compoundHCID 866910899-(Tert-butyl-dimethyl-silanyloxy)-heptadecanedioic acid

Product 1

HCID 58069948HCID 58069948, compoundYield 55.8%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
70 °C

Procedure

To a solution of compound 7 (2.0 g, 12.8 mmol) in toluene (40 mL) and CH2Cl2 (18 mL) and was added 8 (3.96 g, 11.8 mmol). The mixture was heated at 70° C. overnight. Column chromatography gave pure compound 9 (1.40 g, 6.59 mmol, 51%) as a colorless oil.

Sources & evidence

ORD record
ord-d8260a4d2edb47799dfd9d873577ada0
Source dataset
uspto-grants-2015_06
Patent number
US09061063B2

Reaction notes

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