Hydrochloric Acid → HCID 178525419, compound

HRID 2174351Notes

Reaction equation

HRID 2174351 reaction equation
C[O:2][C:3](=[O:37])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:28][CH:27]=2)=[CH:22][CH:21]=1.CO.[OH-].[Na+].Cl>O>[NH:36]1[C:32]([C:29]2[CH:28]=[CH:27][C:26]([C:23]3[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:37])=[O:2])=[CH:21][CH:22]=3)=[CH:31][CH:30]=2)=[N:33][N:34]=[N:35]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 178500257HCID 178500257, compound

Product 1

HCID 178525419HCID 178525419, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 16-(4′-(5-tetrazolyl)biphenyl-4-yloxy)hexadecanoic acid methyl ester (2.87 g, 5.66 mmol), MeOH (30 ml), and a solution of NaOH (1.51 g, 37.8 mmol) in water (2.0 ml) was stirred at 70° C. After 4 d water (100 ml) and 1N HCl (50 ml) were added, and the product was filtered, washed with water, coevaporated with MeCN/PhMe, and dried under reduced pressure. 2.68 g (96%) of 16-(4′-(5-tetrazolyl)biphenyl-4-yloxy)hexadecanoic acid was obtained.

Workup

  1. filtrationthe product was filtered
  2. washwashed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-10607909bfa94c4596f180427da76d58
Source dataset
uspto-grants-2015_06
Patent number
US09061067B2

Reaction notes

Loading…