Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → HCID 67627060, compound

HRID 2174436Notes

Reaction equation

HRID 2174436 reaction equation
[CH2:1]([N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([OH:17])=[C:9]([C:18]([O:20]CC)=O)[C:8]1=[O:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[NH2:24][C:25]1[CH:37]=[CH:36][C:28]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[CH2:1]([N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([OH:17])=[C:9]([C:18]([NH:24][C:25]2[CH:37]=[CH:36][C:28]([C:29]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:30])=[CH:27][CH:26]=2)=[O:20])[C:8]1=[O:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 233272Benzoic acid, 4-amino-, 1,1-dimethylethyl esterHCID 54679210HCID 54679210, compound

Product 1

HCID 67627060HCID 67627060, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ethyl 1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (159 mg, 0.5 mmol) and tert-butyl 4-aminobenzoate (193 mg, 1 mmol) are suspended in anhydrous toluene (4 ml) and are microwave-heated with the container open (the parameters are the following: power=200 W, temperature=120° C., execution time=7 min, hold time=10 min).

Workup

  1. temperatureare microwave-heated with the container open (the parameters
  2. custompower=200 W, temperature=120° C., execution time=7 min
  3. customtime=10 min

Sources & evidence

ORD record
ord-e14c7f55c10246e3a69a5024f3539b8c
Source dataset
uspto-grants-2015_06
Patent number
US09061997B2

Reaction notes

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