反应详情

30.0 g (174 mmol) of 1,4-diacetoxy-2-butene (trans/cis=85/15), 150 mL of toluene, and 300 mL of a 50% sodium hydroxide aqueous solution were added into a four-necked flask (1 L), and thereafter, 2.81 g (8.71 mmol) of tetra-n-butylammonium bromide was added thereto as a phase-transfer catalyst. The obtained mixture was stirred at room temperature for 1 hour, and 79.7 g (418 mmol) of 4-toluenesulfonyl chloride was then added to the reaction solution. The obtained mixture was stirred at room temperature for 5 hours, and 480 mL of water and 150 mL of toluene were then added to the reaction solution to facilitate liquid separation. The mixture was stirred, and an organic layer was then separated. A water layer was re-extracted with 150 mL of toluene, and organic layers were then gathered. The gathered organic layer was washed with 120 mL of water three times, and the resultant was filtrated, while washing the residue with toluene. The obtained filtrate was concentrated at 45° C. under reduced pressure. Thereafter, 60 mL of toluene was added to the residue, and the residue was completely dissolved therein at 60° C. Thereafter, the obtained solution was gradually cooled to 0° C., and it was then stirred for 1 hour. The precipitated crystal was collected by filtration. The obtained crystal was washed with 30 mL of cold toluene, and it was then dried at room temperature, so as to obtain 35.4 g of trans-1,4-di-4-toluenesulfonyloxy-2-butene in the form of a colorless crystal (yield: 51%, trans/cis=100/0). As a result of NMR analysis, the colorless crystal was confirmed to be trans-1,4-di-4-toluenesulfonyloxy-2-butene.

1. stirringThe obtained mixture was stirred at room temperature for 5 hours
2. customliquid separation
3. stirringThe mixture was stirred
4. customan organic layer was then separated
5. extractionA water layer was re-extracted with 150 mL of toluene, and organic layers
6. washThe gathered organic layer was washed with 120 mL of water three times
7. filtrationthe resultant was filtrated
8. washwhile washing the residue with toluene
9. concentrationThe obtained filtrate was concentrated at 45° C. under reduced pressure
10. additionThereafter, 60 mL of toluene was added to the residue
11. dissolutionthe residue was completely dissolved
12. customat 60° C
13. temperatureThereafter, the obtained solution was gradually cooled to 0° C.
14. stirringit was then stirred for 1 hour
15. filtrationThe precipitated crystal was collected by filtration
16. washThe obtained crystal was washed with 30 mL of cold toluene, and it
17. customwas then dried at room temperature