Propylamine → HCID 53353685, compound

HRID 2174530Notes

Reaction equation

[Cl:1][C:2]1[C:3](=[O:19])[N:4]([CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[CH2:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:5]=[CH:6][C:7]=1Cl.[CH2:20]([NH2:23])[CH2:21][CH3:22]>>[Cl:1][C:2]1[C:3](=[O:19])[N:4]([CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[CH2:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:5]=[CH:6][C:7]=1[NH:23][CH2:20][CH2:21][CH3:22]

Participants

Reactant 2

HCID 7852Propylamine

HCID 53353682HCID 53353682, compound

Product 1

HCID 53353685HCID 53353685, compound

Procedure

4-Chloro-5-n-propylamino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one was prepared from 4,5-Dichloro-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one in a similar manner using n-propylamine (4 equivalents). 1H NMR (300 MHz CDCl3) 7.6 (s, 1H), 5.3 (m, 1H), 4.65 (brs, 1H), 3.5 (q, 2H, J=7 Hz), 1.72 (q, 2H, J=7 Hz), 1.55 (m, 4H), 1.3 (m, 1H), 1.15 (m, 1H), 1.15 (s, 6H), 1.04 (t, 3H, J=7 Hz), 0.95 (s, 6H).

Sources & evidence

ORD record: ord-5ae1f6cd94b147fa8fab6f1f3db5b753
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09062004B2

Reaction notes

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