2-Morpholinoethylamine → HCID 53353784, compound

HRID 2174533Notes

Reaction equation

[Br:1][C:2]1[C:3](=[O:19])[N:4]([CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[CH2:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:5]=[CH:6][C:7]=1Br.[O:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][NH2:28])[CH2:22][CH2:21]1>>[Br:1][C:2]1[C:3](=[O:19])[N:4]([CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[CH2:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:5]=[CH:6][C:7]=1[NH:28][CH2:27][CH2:26][N:23]1[CH2:24][CH2:25][O:20][CH2:21][CH2:22]1

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 67364939HCID 67364939, compound

Product 1

HCID 53353784HCID 53353784, compound

Procedure

4-Bromo-5-(2-morpholinoethyl)amino-2-(3,3,5,5-tetramethylcyclohexyl)pyridazin-3-one was prepared from 4,5-Dibromo-2-(3,3,5,5-tetramethyl cyclohexyl)pyridazin-3-one in a similar manner using 2-Morpholinoethyl amine (4 equivalents). 1H NMR (300 MHz CDCl3) 7.51 (s, 1H), 5.67 (m, 1H), 5.33 (m, 1H), 3.78 (m, 4H), 3.38 (m, 2H), 2.70 (m, 2H), 2.52 (m, 4H), 1.55 (m, 4H), 1.3 (m, 1H), 1.15 (m, 1H), 1.15 (s, 6H), 0.95 (s, 6H)

Sources & evidence

ORD record: ord-7e79225d850a48258cfb8acaba63d9d0
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09062004B2

Reaction notes

Loading…