Hydrochloric Acid → HCID 131732981, compound

Participants

Reaction Steps

To a Schlenk reactor, 30 mL of deionized water was added, followed by 5 g (44.3 mmol) of creatinine. Under a high-purity argon atmosphere, the mixture was heated with stirring. After the temperature in reactor reached up to the predetermined temperature of 60° C., an aqueous solution of hydrochloric acid at a concentration of 18.5% was added via a constant pressure dropping funnel into the reactor. The molar ratio between creatinine and hydrochloride was set as 1:1.1. The reaction was kept with stirring for 4 h. By using a rotary evaporator, the moisture contained in the system was removed under reduced pressure. The solid product was transferred into a vacuum oven and dried at room temperature for 48 h, to give 6.52 g of creatinine-guanidinium chloride as a snow white solid product.

Provenance & Evidence