Hydrochloric Acid → HCID 131732981, compound

HRID 2174539Notes

Reaction equation

HRID 2174539 reaction equation
[CH3:1][N:2]1[C:7]([NH2:8])=[N:6][C:4](=[O:5])[CH2:3]1.[ClH:9]>O>[CH3:1][N:2]1[C:7]([NH2:8])=[N:6][C:4](=[O:5])[CH2:3]1.[Cl-:9].[NH2:6][C:7]([NH2:8])=[NH2+:2]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 588creatinine2×

Product 1

HCID 131732981HCID 131732981, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a Schlenk reactor, 30 mL of deionized water was added, followed by 5 g (44.3 mmol) of creatinine. Under a high-purity argon atmosphere, the mixture was heated with stirring. After the temperature in reactor reached up to the predetermined temperature of 60° C., an aqueous solution of hydrochloric acid at a concentration of 18.5% was added via a constant pressure dropping funnel into the reactor. The molar ratio between creatinine and hydrochloride was set as 1:1.1. The reaction was kept with stirring for 4 h. By using a rotary evaporator, the moisture contained in the system was removed under reduced pressure. The solid product was transferred into a vacuum oven and dried at room temperature for 48 h, to give 6.52 g of creatinine-guanidinium chloride as a snow white solid product.

Workup

  1. temperatureUnder a high-purity argon atmosphere, the mixture was heated
  2. customAfter the temperature in reactor reached up to the predetermined temperature of 60° C.
  3. stirringwith stirring for 4 h
  4. customa rotary evaporator
  5. customwas removed under reduced pressure
  6. customdried at room temperature for 48 h

Sources & evidence

ORD record
ord-ba0dc78db886496a952ddad36ed0506c
Source dataset
uspto-grants-2015_06
Patent number
US09062006B2

Reaction notes

Loading…