[1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acid → 4-Piperidineacetic acid hydrochloride

HRID 217454Notes

Reaction equation

HRID 217454 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.O1CCOCC1.[ClH:24]>O1CCOCC1>[ClH:24].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:17])=[O:16])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 1512539[1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acidHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 155657754-Piperidineacetic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of [1-(tert-butoxycarbonyl)piperidin-4-yl]acetic acid (200 mg) in dioxane (1 mL) was added a 4 M hydrogen chloride dioxane solution (1 mL). The reaction liquid was stirred at room temperature for 15 hours, and then concentrated under reduced pressure to obtain piperidin-4-yl acetic acid hydrochloride (140 mg) as a white solid.

Workup

  1. customThe reaction liquid
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e63eeb54983f402a93038deb87fca71d
Source dataset
uspto-grants-2012_06
Patent number
US08193378B2

Reaction notes

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