[1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acid → 4-Piperidineacetic acid hydrochloride

Participants

Reaction Steps

To a solution of [1-(tert-butoxycarbonyl)piperidin-4-yl]acetic acid (200 mg) in dioxane (1 mL) was added a 4 M hydrogen chloride dioxane solution (1 mL). The reaction liquid was stirred at room temperature for 15 hours, and then concentrated under reduced pressure to obtain piperidin-4-yl acetic acid hydrochloride (140 mg) as a white solid.

Provenance & Evidence