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HRID2174602

反应详情

EQUATION

反应方程式

HRID 2174602 的结构方程式

REACTANTS

反应物

2
结构：Cc1cnc(N)s1
HCID351770

2-Amino-5-methyl-thiazole

C4H6N2S

结构：CC1(C)[C@@H](C(=O)O)[C@@H]1c1ccccc1
HCID68582304

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cnc(NC(=O)[C@H]2[C@H](c3ccccc3)C2(C)C)s1
HCID86709735

未命名化合物

收率 61.8%

PROCEDURE

实验过程

2,2-Dimethyl-trans-3-phenylcyclopropanecarboxylic acid (250 mg, 1.32 mmol) and 2-amino-5-methylthiazole (150 mg, 1.31 mmol) were reacted as described under General Procedure D to furnish the title compound (232 mg, 61%) as a yellow foam. 1H NMR (300 MHz, CDCl3) δ 7.33-7.17 (m, 6H), 7.02 (s, 1H), 2.95 (d, J=5.6 Hz, 1H), 2.37 (s, 3H), 2.08 (d, J=5.6 Hz, 1H), 1.44 (s, 3H), 1.03 (s, 3H). mp 132-135° C. ESIMS m/z [M+H]+ 287.1.