Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Chloride | HCID 4873 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 89650324 | HCID 89650324 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 20067183 | HCID 20067183 | — |
Reaction Steps
To a solution of 6-cyclopropyl-pyridine-2,3-dicarboxylic acid dimethyl ester (D81, 12.6 g, 53.62 mmol) in methanol (90 ml) and water (30 ml) was added potassium hydroxide (9.02 g, 160.86 mmol) at 0˜5° C. After heated to 60° C. for 2 hours, the mixture was acidified with 1N HCl until pH=5 and then concentrated to give D82 (21.34 g, containing KCl) as a grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09062033B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-26c2191e2c0a43d0a11d643741c943dd |
|---|
| Source note | uspto-grants-2015_06 |
|---|
