Hydrochloric Acid → HCID 20067183, compound

HRID 2174687Notes

Reaction equation

HRID 2174687 reaction equation
C[O:2][C:3]([C:5]1[C:10]([C:11]([O:13]C)=[O:12])=[CH:9][CH:8]=[C:7]([CH:15]2[CH2:17][CH2:16]2)[N:6]=1)=[O:4].[OH-].[K+].Cl.[Cl-].[K+]>CO.O>[CH:15]1([C:7]2[N:6]=[C:5]([C:3]([OH:4])=[O:2])[C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=2)[CH2:16][CH2:17]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 4873Potassium ChlorideHCID 14797Potassium HydroxideHCID 89650324HCID 89650324, compound

Product 1

HCID 20067183HCID 20067183, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 6-cyclopropyl-pyridine-2,3-dicarboxylic acid dimethyl ester (D81, 12.6 g, 53.62 mmol) in methanol (90 ml) and water (30 ml) was added potassium hydroxide (9.02 g, 160.86 mmol) at 0˜5° C. After heated to 60° C. for 2 hours, the mixture was acidified with 1N HCl until pH=5 and then concentrated to give D82 (21.34 g, containing KCl) as a grey solid.

Workup

  1. concentrationconcentrated
  2. customto give

Sources & evidence

ORD record
ord-26c2191e2c0a43d0a11d643741c943dd
Source dataset
uspto-grants-2015_06
Patent number
US09062033B2

Reaction notes

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