反应详情

To 5,6-dichloronicotinic acid (2.2 g) was added 1,1,1-trimethoxyethane (4.3 mL), followed by irradiation with microwave at 120° C. for 15 minutes. The reaction mixture was dissolved in EtOAc and washed with water. The organic layer was dried over MgSO4 and the vehicle was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:EtOAc=85:15 to 80:20) to obtain methyl 5,6-dichloronicotinate (2.2 g) as a white solid.

1. customfollowed by irradiation with microwave at 120° C. for 15 minutes
2. washwashed with water
3. dry with materialThe organic layer was dried over MgSO4
4. customthe vehicle was evaporated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (hexane:EtOAc=85:15 to 80:20)