Trifluoroacetic acid → HCID 67086667, compound

HRID 2174972Notes

Reaction equation

HRID 2174972 reaction equation
C(OC([N:8]1[CH2:15][CH2:14][CH:13]2[CH:10]([N:11]([C:16]([C:18]3[C:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:20][CH:21]=[CH:22][CH:23]=3)=[O:17])[CH2:12]2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>O1CCOCC1>[C:19]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16]([N:11]1[CH:10]2[CH:13]([CH2:14][CH2:15][NH:8][CH2:9]2)[CH2:12]1)=[O:17]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67086573HCID 67086573, compound

Product 1

HCID 67086667HCID 67086667, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 8-(biphenyl-2-carbonyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester in dioxane (8.0 mL) was added trifluoro acetic acid (3 mL), the reaction mixture was stirred for 16 h at room temperature. The solvent and the excess of trifluoro acetic acid were removed under reduced pressure. The resulting trifluoro acetic acid salt of the title compound (388.0 mg was used crude without further purification. MS (ESI) mass calcd. for C19H20N2O, 292.37; m/z found, 293.2 [M+H]+.

Workup

  1. customThe solvent and the excess of trifluoro acetic acid were removed under reduced pressure
  2. customwithout further purification

Sources & evidence

ORD record
ord-3d9f1bf10e9b4ec69639be730a949fe8
Source dataset
uspto-grants-2015_06
Patent number
US09062044B2

Reaction notes

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