Trifluoroacetic acid → HCID 67086591, compound

HRID 2174976Notes

Reaction equation

HRID 2174976 reaction equation
C(OC([N:8]1[CH2:15][CH2:14][CH:13]2[CH:10]([N:11]([C:16]([C:18]3[S:22][C:21]([CH3:23])=[N:20][C:19]=3[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])=[O:17])[CH2:12]2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>O1CCOCC1>[CH:10]12[N:11]([C:16]([C:18]3[S:22][C:21]([CH3:23])=[N:20][C:19]=3[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])=[O:17])[CH2:12][CH:13]1[CH2:14][CH2:15][NH:8][CH2:9]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67086717HCID 67086717, compound

Product 1

HCID 67086591HCID 67086591, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 8-[4-(2-fluoro-phenyl)-2-methyl-thiazole-5-carbonyl]-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester in dioxane (8 mL) was added trifluoro acetic acid (3 mL), the reaction mixture was stirred for 16 h at room temperature. The solvent and the excess of trifluoro acetic acid were removed under reduced pressure. The resulting trifluoro acetic acid salt of the title compound was used crude without further purification (54.0 mg, 56%). MS (ESI) mass calcd. for C17H18FN3OS, 331.41; m/z found, 332.2 [M+H]+.

Workup

  1. customThe solvent and the excess of trifluoro acetic acid were removed under reduced pressure
  2. customwithout further purification (54.0 mg, 56%)

Sources & evidence

ORD record
ord-113f716096c8431889955b92dc411b7a
Source dataset
uspto-grants-2015_06
Patent number
US09062044B2

Reaction notes

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