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HRID2174977

反应详情

EQUATION

反应方程式

HRID 2174977 反应方程式

REACTANTS

反应物

4
2-(Thiophen-2-yl)benzoyl chloride 分子结构式
HCID2795557

2-(Thiophen-2-yl)benzoyl chloride

C11H7ClOS

[1,1'-Biphenyl]-2-carbonyl chloride 分子结构式
HCID12563768

[1,1'-Biphenyl]-2-carbonyl chloride

C13H9ClO

HCID 43810891 分子结构式
HCID43810891

未命名化合物

HCID 67086667 分子结构式
HCID67086667

未命名化合物

PRODUCTS

产物

1
HCID 89593632 分子结构式
HCID89593632

未命名化合物

收率 66.7%

PROCEDURE

实验过程

Intermediate 7 was prepared in a manner analogous to Intermediate 3, substituting (1R,6S) 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester for 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester and 2-thiophen-2-yl-benzoyl chloride for biphenyl-2-carbonyl chloride in Step A. The final compound was concentrated and the residue was purified on HPLC to provide the title compound (150 mg, 66.7%). MS (ESI) mass calcd. for C17H18N2OS, 298.4; m/z found, 299.2. [M+H]+.

WORKUP

后处理

  1. concentrationThe final compound was concentrated
  2. customthe residue was purified on HPLC