HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Thiophen-2-yl)benzoyl chloride → HCID 89593632, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Thiophen-2-yl)benzoyl chloride | HCID 2795557 | — |
| Reactant | [1,1'-Biphenyl]-2-carbonyl chloride | HCID 12563768 | — |
| Reactant | Tert-butyl 3,8-diazabicyclo[4.2.0]octane-3-carboxylate | HCID 43810891 | — |
| Reactant | HCID 67086667 | HCID 67086667 | — |
| Product | HCID 89593632 | HCID 89593632 | 66.7% |
Reaction Steps
Intermediate 7 was prepared in a manner analogous to Intermediate 3, substituting (1R,6S) 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester for 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester and 2-thiophen-2-yl-benzoyl chloride for biphenyl-2-carbonyl chloride in Step A. The final compound was concentrated and the residue was purified on HPLC to provide the title compound (150 mg, 66.7%). MS (ESI) mass calcd. for C17H18N2OS, 298.4; m/z found, 299.2. [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062044B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d3cafa97afa446fe9bd4865fb627d0e3 |
| Source note | uspto-grants-2015_06 |