Trifluoroacetic acid → (1S,6R)-3,8-Diazabicyclo[4.2.0]octan-8-yl(2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)methanone

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Reaction Steps

The product of Step B (645 mg, 1.63 mmol), DCM (8 mL), TFA (3 mL) were stirred at room temperature for 2 h and then concentrated in vacuo. The residue was dissolved in DCM and treated with Dowex 550 A resin. After stirring for 2 h the resin was removed by filtration and the filtrate was concentrated in vacuo to a colorless oil which was taken on to the next step without further purification. MS (ESI) mass calculated for C16H18N4O2, 298.14; m/z found, 299.1.

Provenance & Evidence