(1S,6R)-3,8-Diazabicyclo[4.2.0]octan-8-yl(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone → (1S,6R)-3,8-Diazabicyclo[4.2.0]octan-8-yl(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

HRID 2175002Notes

Reaction equation

HRID 2175002 reaction equation
[C@H:1]12[N:8]([C:9]([C:11]3[C:16]([N:17]4[N:21]=[CH:20][CH:19]=[N:18]4)=[CH:15][CH:14]=[CH:13][C:12]=3F)=[O:10])[CH2:7][C@H:6]1[CH2:5][CH2:4][NH:3][CH2:2]2.[F:23]C1C=CC=C(N2N=CC=N2)C=1C(O)=O>>[C@H:1]12[N:8]([C:9]([C:11]3[CH:12]=[C:13]([F:23])[CH:14]=[CH:15][C:16]=3[N:17]3[N:21]=[CH:20][CH:19]=[N:18]3)=[O:10])[CH2:7][C@H:6]1[CH2:5][CH2:4][NH:3][CH2:2]2

Participants

3

Reactant 2

HCID 67086546(1S,6R)-3,8-Diazabicyclo[4.2.0]octan-8-yl(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanoneHCID 670866272-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 67086569(1S,6R)-3,8-Diazabicyclo[4.2.0]octan-8-yl(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Procedure

The title compound was prepared in a manner analogous to Intermediate 28, substituting 5-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid for 2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid. MS (ESI) mass calcd. C15H16FN5O, 301.32; m/z found 302.0 [M+H]+.

Sources & evidence

ORD record
ord-49a77b3e3d43469aabb0fb499bc57716
Source dataset
uspto-grants-2015_06
Patent number
US09062044B2

Reaction notes

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