5-Fluoro-2-iodobenzoic acid → 4-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

HRID 2175016Notes

Reaction equation

HRID 2175016 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:16]C1C=CC(I)=C(C=1)C(O)=O>>[F:16][C:3]1[CH:2]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)[CH:4]=1

Participants

3

Reactant 2

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 670868864-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Procedure

The title compound was prepared in a manner analogous to Intermediate 41, substituting 4-fluoro-2-iodo-benzoic acid for 5-fluoro-2-iodo-benzoic acid. 1H NMR (400 MHz, CD3OD): 7.93 (s, 2H), 7.88 (dd, J=8.7, 5.9 Hz, 1H), 7.56 (dd, J=9.2, 2.5 Hz, 1H), 7.38-7.30 (m, 1H).

Sources & evidence

ORD record
ord-7ad9ec04e77d499bb41d7f487e59c26f
Source dataset
uspto-grants-2015_06
Patent number
US09062044B2

Reaction notes

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