HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1104389-11-8
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Paliperidone | HCID 115237 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1104389-11-8 | HCID 77215917 | — |
Reaction Steps
125.0 ml methanol and 25.0 grams g of paliperidone were charged into round bottom flask. The pH of the reaction mixture was adjusted to 2.0 to 3.0 with IPA.HCl. The reaction mixture was stirred, cooled, filtered and dried under vacuum to obtain paliperidone hydrochloride. Dry wt 25.0 grams.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09062049B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-71521286558641df84e29222aefb5128 |
| Source note | uspto-grants-2015_06 |