Hydrochloric Acid → 1104389-11-8

HRID 2175049Notes

Reaction equation

HRID 2175049 reaction equation
CO.[CH3:3][C:4]1[N:14]=[C:13]2[N:8]([CH2:9][CH2:10][CH2:11][CH:12]2[OH:15])[C:6](=[O:7])[C:5]=1[CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[C:25]3[CH:26]=[CH:27][C:28]([F:33])=[CH:29][C:30]=3[O:31][N:32]=2)[CH2:20][CH2:19]1.[ClH:34]>CC(O)C>[CH3:3][C:4]1[N:14]=[C:13]2[N:8]([CH2:9][CH2:10][CH2:11][CH:12]2[OH:15])[C:6](=[O:7])[C:5]=1[CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[C:25]3[CH:26]=[CH:27][C:28]([F:33])=[CH:29][C:30]=3[O:31][N:32]=2)[CH2:20][CH2:19]1.[ClH:34]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 115237Paliperidone

Product 1

HCID 772159171104389-11-8

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

125.0 ml methanol and 25.0 grams g of paliperidone were charged into round bottom flask. The pH of the reaction mixture was adjusted to 2.0 to 3.0 with IPA.HCl. The reaction mixture was stirred, cooled, filtered and dried under vacuum to obtain paliperidone hydrochloride. Dry wt 25.0 grams.

Workup

  1. additionwere charged into round bottom flask
  2. temperaturecooled
  3. filtrationfiltered
  4. customdried under vacuum

Sources & evidence

ORD record
ord-71521286558641df84e29222aefb5128
Source dataset
uspto-grants-2015_06
Patent number
US09062049B2

Reaction notes

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