tert-Butyl 4-(3-bromophenyl)piperazine-1-carboxylate → 4-[3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

HRID 2175070Notes

Reaction equation

HRID 2175070 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16](Br)[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC1(C)C(C)(C)OB([C:29]2[CH:38]=[CH:37][C:36]3[C:35]([CH3:40])([CH3:39])[CH2:34][CH2:33][C:32]([CH3:42])([CH3:41])[C:31]=3[CH:30]=2)O1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:38]3[CH:29]=[CH:30][C:31]4[C:32]([CH3:42])([CH3:41])[CH2:33][CH2:34][C:35]([CH3:40])([CH3:39])[C:36]=4[CH:37]=3)[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 10882380tert-Butyl 4-(3-bromophenyl)piperazine-1-carboxylateHCID 112439294,4,5,5-Tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane

Product 1

HCID 672492564-[3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

Procedure

The preparation is carried out analogously to FS 102 starting from 4-(3-bromophenyl)piperazine-1-carboxylic acid tert-butyl ester (WO2007/97937) and 4,4,5,5-tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane.

Sources & evidence

ORD record
ord-f69d9a95b097418a9839d9d1d9b7f8c1
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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