tert-Butyl 4-(3-bromophenyl)piperazine-1-carboxylate → 4-[3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl 4-(3-bromophenyl)piperazine-1-carboxylate	HCID 10882380	—
Reactant	4,4,5,5-Tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane	HCID 11243929	—
Product	4-[3-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester	HCID 67249256	—

Reaction Steps

The preparation is carried out analogously to FS 102 starting from 4-(3-bromophenyl)piperazine-1-carboxylic acid tert-butyl ester (WO2007/97937) and 4,4,5,5-tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09062015B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-f69d9a95b097418a9839d9d1d9b7f8c1
Source note	uspto-grants-2015_06