Hydrochloric Acid → 1-[6-(5,5-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]-piperazine

HRID 2175074Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[CH:29]=[CH:28][C:27]4[C:26]([CH3:31])([CH3:30])[CH2:25][CH2:24][CH2:23][C:22]=4[CH:21]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>>[CH3:30][C:26]1([CH3:31])[CH2:25][CH2:24][CH2:23][C:22]2[CH:21]=[C:20]([C:16]3[N:15]=[C:14]([N:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)[CH:19]=[CH:18][CH:17]=3)[CH:29]=[CH:28][C:27]1=2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 672484724-[6-(5,5-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 683310171-[6-(5,5-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]-piperazine

Procedure

The above compound is prepared analogously to FS201 starting from 4-[6-(5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester. Product is the hydrochloride.

Workup

customThe above compound is prepared analogously to FS201

Sources & evidence

ORD record: ord-0b3aef3f162241e38401d928996f779a
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09062015B2

Reaction notes

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