Hydrochloric Acid → HCID 68380210, compound

HRID 2175079Notes

Reaction equation

C(OC(=O)[NH:7][CH:8]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:18][CH2:17][N:16]([C:19]3[N:24]=[C:23]([C:25]4[CH:34]=[CH:33][C:32]5[C:31]([CH3:36])([CH3:35])[CH2:30][CH2:29][C:28]([CH3:38])([CH3:37])[C:27]=5[CH:26]=4)[N:22]=[CH:21][N:20]=3)[CH2:15][CH2:14]2)[CH2:9]1)(C)(C)C.Cl>>[CH3:35][C:31]1([CH3:36])[CH2:30][CH2:29][C:28]([CH3:37])([CH3:38])[C:27]2[CH:26]=[C:25]([C:23]3[N:22]=[CH:21][N:20]=[C:19]([N:16]4[CH2:15][CH2:14][CH:13]([N:10]5[CH2:11][CH2:12][CH:8]([NH2:7])[CH2:9]5)[CH2:18][CH2:17]4)[N:24]=3)[CH:34]=[CH:33][C:32]1=2

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 67247802HCID 67247802, compound

Product 1

HCID 68380210HCID 68380210, compound

Procedure

The above compound is prepared analogously to FS201 starting from (1-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,5-triazin-2-yl]piperidin-4-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester. The product is in the form of the hydrochloride.

Workup

customThe above compound is prepared analogously to FS201

Sources & evidence

ORD record: ord-36a7fb5094964dda8846c1c2a6605e39
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09062015B2

Reaction notes

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